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MU study finds that sitting may increase risk of disease

Public release date: 19-Nov-2007

 

COLUMBIA, Mo. – Most people spend most of their day sitting with relatively idle muscles. Health professionals advise that at least 30 minutes of activity at least 5 days a week will counteract health concerns, such as cardiovascular disease, diabetes and obesity that may result from inactivity. Now, researchers at the University of Missouri-Columbia say a new model regarding physical activity recommendations is emerging. New research shows that what people do in the other 15 and a half hours of their waking day is just as important, or more so, than the time they spend actively exercising.

In a series of studies that will be presented at the Second International Congress on Physical Activity and Public Health in Amsterdam, Hamilton, Theodore Zderic, a post-doctoral researcher, and their research team studied the impact of inactivity among rats, pigs and humans. In humans, they studied the effects of sitting in office chairs, using computers, reading, talking on the phone and watching TV. They found evidence that sitting had negative effects on fat and cholesterol metabolism. The researchers also found that physical inactivity throughout the day stimulated disease-promoting processes, and that exercising, even for an hour a day, was not sufficient to reverse the effect.

“The enzymes in blood vessels of muscles responsible for ‘fat burning’ are shut off within hours of not standing,” Hamilton said. “Standing and moving lightly will re-engage the enzymes, but since people are awake 16 hours a day, it stands to reason that when people sit much of that time they are losing the opportunity for optimal metabolism throughout the day.”

Only 28 percent of Americans are getting the minimal amount of recommended exercise. Hamilton predicts that eventually there will be health campaigns with doctors advocating limiting sitting time, just like they ask people to limit sun and second hand smoke exposure.

“The purpose of medical research is to offer effective new strategies for people whom the existing therapies are not working,” Hamilton said. “Because our research reveals that too little exercise and excessive sitting do not change health by the same genes and biological mechanisms, it offers hope for people who either are not seeing results from exercise or can not exercise regularly. The lifestyle change we are studying is also unlike exercise because it does not require that people squeeze an extra hour into their days and/or get sweaty at the gym, but instead improving the quality of what they already are doing. One misrepresentation is that people tend to say ‘I sit all the time, so your studies suggest that I can’t even work,’ but Ben Franklin and Thomas Jefferson showed us that you can be very productive and still do great work in an office with a ‘standing’ desk.”

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