Probiotics increase bone volume in healthy mice

“We were surprised by the potency of the gut microbiome in regulating bone and by the complexity of the mechanism of action of probiotics,” Pacifici says. “In general, there is a lot of interest in the concept that the gut bacteria regulate the function of distant organs. How this happens is largely unknown. We described a detailed mechanism by which changes in the composition of the gut microbiome induced by probiotics affect a distant system like the skeleton.”

Immunity, Tyagi and Yu et al.: “The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression” https://www.cell.com/immunity/fulltext/S1074-7613(18)30478-3 , DOI: 10.1016/j.immuni.2018.10.013

Lactobacillus rhamnosus GG, butyrate, microbiota, bone formation, probiotics, short-chain fatty acids, Wnt10b, NFAT, T cells, regulatory T cell, bone volume, bone density, skeletal, spine