Administration of these agents after mice have developed full colitis has reversed the phenotype significantly by reducing shortening of colons, gut permeability, and inflammation. When animals were fed with UroA or its synthetic analog prior to insulting with TNBS, mice did not develop colitis. Therefore, proving the protective nature of these compounds against gut inflammation. These results suggest that UroA/UAS03 mediated enhanced gut barrier function will likely have long-term beneficial effects in preventing colitis.

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

doi.org/10.1038/s41467-018-07859-7DO – 10.1038/s41467-018-07859-7ID – Singh2019ER