Sil-ibin-in from milk thistle seeds as novel, non-invasive treatment strategy for Cushing Disease
– After silibinin treatment, tumour cells resumed normal ACTH production, tumour growth slowed down and symptoms of Cushing Disease disappeared in mice.
– . “We found that silibinin binds to HSP90 thus allowing glucocorticoid receptor molecules to dissolve from HSP90. With silibinin we might have discovered a non-invasive treatment strategy not only for the rare Cushing Disease but also for other conditions with the involvement of glucocorticoid receptors such as lung tumours, acute lymphoblastic leukaemia or multiple myeloma,”
*A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease
Nature Medicine (2015) doi:10.1038/nm.3776
– http://healthresearchreport.me/2015/02/12/silibinin-from-milk-thistle-seeds-fights-brain-tumor/
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