Keeping older muscles strong
Scientists at the University of Iowa have discovered the first example of a protein that causes muscle weakness and loss during aging. The protein, ATF4, is a transcription factor that alters gene expression in skeletal muscle, causing reduction of muscle protein synthesis, strength, and mass. The UI study also identifies two natural compounds, one found in apples and one found in green tomatoes, which reduce ATF4 activity in aged skeletal muscle. The findings, which were published online Sept. 3 in the Journal of Biological Chemistry, could lead to new therapies for age-related muscle weakness and atrophy.
“By reducing ATF4 activity, ursolic acid and tomatidine allow skeletal muscle to recover from effects of aging,”
Ursolic Acid or Tomatidine in 2 Months
10% Increase Muscle Mass 30% Increase in Strength
Animal Study
* Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
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