Aging is often accompanied by a decline in organ function, and the urinary tract is no exception. This video explores how cellular aging within the bladder contributes to increased vulnerability to urinary tract infections (UTIs). By understanding these age-related changes, we aim to identify potential anti-aging strategies that can improve bladder health and reduce the risk of UTIs. Our research offers insights into preserving urinary tract function as we age and highlights the potential of natural compounds like D-mannose in supporting overall well-being.

#aging #mannose #urinarytractinfection #UTI #bladderhealth #autophagy #oxidativestress #Dmannose #cellularaging #antiaging #urothelialcells

Joshi CS, Salazar AM, Wang C, Ligon MM, Chappidi RR, Fashemi BE, Felder PA, Mora A, Grimm SL, Coarfa C, Mysorekar IU. D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell. 2024 Jan 8;59(1):33-47.e5. doi: 10.1016/j.devcel.2023.11.017. Epub 2023 Dec 14. PMID: 38101412; PMCID: PMC10872954.

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