Academic Summary
A 2×2 factorial randomized controlled trial evaluated the effects of 20g/day of inulin prebiotic supplementation alongside digital physiotherapy-supported exercise on 117 adults with knee osteoarthritis over 6 weeks. Both interventions produced clinically meaningful reductions in pain compared to a maltodextrin placebo. However, only inulin improved pressure pain thresholds, temporal summation, and grip strength. These physical improvements in the inulin group were associated with increased serum levels of glucagon-like peptide-1 (GLP-1) and short-chain fatty acids like butyrate.
Formal AMA Citation
Kouraki A, Franks S, Vijay A, et al. Effect of Prebiotic Supplementation With and Without Physiotherapy on Pain and Pain Sensitivity in People with Knee Osteoarthritis. Nutrients. 2026;18:714.
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