Breaking News

Normal Human Gut Bacteria May Inhibit Shiga Toxin Development Following Infection with E. coli O157:H7

0 0

Public release date: 3-Mar-2009

A new study suggests that normal human intestinal bacteria may inhibit the development of Shiga toxin 2 (Stx2), the toxin responsible for causing the more severe symptoms associated with food-borne disease, following Escherichia coli O157:H7 infection. The researchers from France report their findings in the February 2009 issue of the journal Infection and Immunity.

Enterohemorrhagic E. coli O157:H7 causes food-borne disease with symptoms ranging from diarrhea and hemorrhagic colitis to potentially fatal hemolytic-uremic syndrome. Stx2 is released in the gut following oral ingestion of E. coli O157:H7 and is the main virulence factor responsible for the more serious complications from the disease. Despite what researchers already know about the role of Stx2 in the progression of the disease, how the molecules released by the normal intestinal bacteria impact Stx2 is largely unknown.

In the study Stx2 synthesis was analyzed following the growth of E. coli O157:H7 in contents collected from the large bowel of rats colonized with normal human intestinal bacteria. Results showed that extracellular molecules, produced in part by Bacteroides thetaiotaomicron (a predominant species of the normal human intestine), repressed Stx2 development.

“Our findings demonstrate for the first time the regulatory activity of a soluble factor produced by the complex human digestive microbiota on a bacterial virulence factor in a physiologically relevant context,” say the researchers.

(T. de Sablet, C. Chassard, A. Bernalier-Donadille, M. Vareille, A.P. Gobert, C. Martin. 2009. Human microbiota-secreted factors inhibit shiga toxin synthesis by enterohemorrhagic Escherichia coli O157:H7. Infection and Immunity, 77. 2: 783-790.)

About Post Author

Ralph Turchiano

I have a strong affinity for the sciences which led me to create my sites. My compulsion for the past decade has been reviewing literally every peer-reviewed research article. Which can easily be validated by following my posts. To me, science is where the real news is, as it will mold our destiny beyond that of politics or economics. 😉 Please feel free to e-mail: 161803p314159@gmail.com
Happy
Happy
0 %
Sad
Sad
0 %
Excited
Excited
0 %
Sleppy
Sleppy
0 %
Angry
Angry
0 %
Surprise
Surprise
0 %

Average Rating

5 Star
0%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
%d bloggers like this: