NIH Study on Omega-3 not being effective for cognitive decline was designed to fail

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( Editors Note: Ralph Turchiano ) Before the media grabs this study as a legitimate study on cognitive decline, they need to look at the dosage used.


1 gram of Omega-3 fat a day ? If the study intervention is accurate, then this was a horrible waste of tax payer dollars. Never mind the untold damage this misinformation may propagate amongst the general population.

  • Just Received Confirmation of just 1 gram of Omega-3 daily

“Participants in the Age-Related Eye Disease Study 2 [AREDS2]), who were at risk for developing late age-related macular degeneration (AMD), were randomly assigned to LCPUFAs (1 g) and/or the dietary supplements lutein (10 mg)/zeaxanthin (2 mg) vs placebo. All participants were also given varying combinations of vitamins C. E. beta carotene, and zinc. In addition to annual eye examinations, several validated cognitive function tests were administered via telephone by trained personnel at baseline and every 2 years during the 5-year study. A total of 89 percent (3,741/4,203) of AREDS2 participants consented to the ancillary cognitive function study and 94 percent (3,501/3,741) underwent cognitive function testing. The average age of the participants was 73 years, and 57.5 percent were women.”


Here is the study as released:

Public Release: 25-Aug-2015 NIH study shows no benefit of omega-3 supplements for cognitive decline

NIH/National Eye Institute

While some research suggests that a diet high in omega-3 fatty acids can protect brain health, a large clinical trial by researchers at the National Institutes of Health found that omega-3 supplements did not slow cognitive decline in older persons. With 4,000 patients followed over a five-year period, the study is one of the largest and longest of its kind. It was published today in the Journal of the American Medical Association.

“Contrary to popular belief, we didn’t see any benefit of omega-3 supplements for stopping cognitive decline,” said Emily Chew, M.D., deputy director of the Division of Epidemiology and Clinical Applications and deputy clinical director at the National Eye Institute (NEI), part of NIH.

Dr. Chew leads the Age-Related Eye Disease Study (AREDS), which was designed to investigate a combination of nutritional supplements for slowing age-related macular degeneration (AMD), a major cause of vision loss among older Americans. That study established that daily high doses of certain antioxidants and minerals–called the AREDS formulation–can help slow the progression to advanced AMD.

A later study, called AREDS2, tested the addition of omega-3 fatty acids to the AREDS formula. But the omega-3’s made no difference. Omega-3 fatty acids are made by marine algae and are concentrated in fish oils; they are believed to be responsible for the health benefits associated with regularly eating fish, such as salmon, tuna, and halibut.* Where studies have surveyed people on their dietary habits and health, they’ve found that regular consumption of fish is associated with lower rates of AMD, cardiovascular disease, and possibly dementia. “We’ve seen data that eating foods with omega-3 may have a benefit for eye, brain, and heart health,” Dr. Chew explained.

Omega-3 supplements are available over the counter and often labeled as supporting brain health. A large 2011 study found that omega-3 supplements did not improve the brain health of older patients with preexisting heart disease.

With AREDS2, Dr. Chew and her team saw another opportunity to investigate the possible cognitive benefits of omega-3 supplements, she said. All participants had early or intermediate AMD. They were 72 years old on average and 58 percent were female. They were randomly assigned to one of the following groups:

1) Placebo (an inert pill)
2) Omega-3 [specifically docosahexaenoic acid (DHA, 350 mg) and eicosapentaenoic acid (650 mg)]
3) Lutein and zeaxanthin (nutrients found in large amounts in green leafy vegetables)
4) Omega-3 and Lutein/zeaxanthin

Because all participants were at risk for worsening of their AMD, they were also offered the original or a modified version of the AREDS formulation (without omega-3 or lutein/zeaxanthin).

Participants were given cognitive function tests at the beginning of the study to establish a baseline, then at two and four years later. The tests, all validated and used in previous cognitive function studies, included eight parts designed to test immediate and delayed recall, attention and memory, and processing speed. The cognition scores of each subgroup decreased to a similar extent over time, indicating that no combination of nutritional supplements made a difference.

Alzheimer’s disease, which is the most common cause of dementia and affects as many as 5.1 million Americans age 65 and older in the U.S., may triple in the next 40 years. Some research has examined the potential benefits of DHA for Alzheimer’s. Studies in mice specially bred to have features of the disease found that DHA reduces beta-amyloid plaques, abnormal protein deposits in the brain that are a hallmark of Alzheimer’s, although a clinical trial of DHA showed no impact on people with mild to moderate Alzheimer’s disease.

“The AREDS2 data add to our efforts to understand the relationship between dietary components and Alzheimer’s disease and cognitive decline,” said Lenore Launer, Ph.D. senior investigator in the Laboratory of Epidemiology and Population Science at the National Institute on Aging. “It may be, for example, that the timing of nutrients, or consuming them in a certain dietary pattern, has an impact. More research would be needed to see if dietary patterns or taking the supplements earlier in the development of diseases like Alzheimer’s would make a difference.”


For more information about AMD and AREDS2, visit

* Other omega-3 fatty acids are found in plant foods such as flaxseed, walnuts, soy products, and canola and soybean oils. Specific omega-3 fatty acids from these sources were not studied.

The cognitive function component of AREDS2 was supported by the NEI Intramural Research Program and contracts HHS-N-260-2005-00007-C. Additional research funds were provided by the NIH Office of Dietary Supplements; the National Center for Complementary and Integrative Health; the National Institute on Aging; the National Heart, Lung, and Blood Institute; and the National Institute of Neurological Disorders and Stroke.

The AREDS trial is registered at as NCT00594672. AREDS2 is registered as NCT00345176.


Age-Related Eye Disease Study 2 (AREDS2) Research Group. “Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial.” JAMA, published online August 25, 2015.

NEI leads the federal government’s research on the visual system and eye diseases. NEI supports basic and clinical science programs that result in the development of sight-saving treatments. For more information, visit

About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit

NIH…Turning Discovery Into Health®


Categories: Corruption - Fabricated Data

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One thought on “NIH Study on Omega-3 not being effective for cognitive decline was designed to fail

  1. Reblogged this on Oil-Change Diet and commented:
    This is something I have said before–drug companies routinely design studies on omega-3 so that they will fail. Low doses, short duration, giving it to people who already have high levels of omega-3 (like Norway). They want to confuse the issue so that they can continue to sell the drugs that a balancing our essential fats will eliminate. You can’t take a disease that develops over a lifetime and do a study that last only a few months of a couple years and expect dramatic results. Drug companies know that people with excessive levels of omega-6 will need 4 to 5 grams of omega-3 per day to balance that omega-6. They know that giving omega-3 to people in countries that don’t consume excessive amounts of omega-6 will have little effect.

    Bottom line–balance is the key! Given the typical western diet with the meats produce by industrial agriculture, unless you are a vegetarian, you have to seriously try to avoid foods high in omega-6 and try to increase your intake of omega-3 to get anywhere close to a balance. Many of those foods that are high in omega-6 are still promoted as “health foods” by dietitians. My book will help you find out which food to avoid or limit to balance your essential fats.

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