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Reversal of lung fibrosis in 21 days mouse with Venetoclax
The bleomycin mice that received ABT-199 had normal lung architecture at 21 days and no collagen deposition. These results suggest a novel therapeutic target to reverse fibrotic remodeling in the lungs.
fibrosis #venetoclax #abt199
Linlin Gu, Ranu Surolia, Jennifer L. Larson-Casey, Chao He, Dana Davis, Jungsoon Kang, Veena B. Antony, A. Brent Carter. Targeting Cpt1a-Bcl-2 interaction modulates apoptosis resistance and fibrotic remodeling. Cell Death & Differentiation, 2021; DOI: 10.1038/s41418-021-00840-w
ABT-199, Venetoclax , bcl-2, collagen , deposition, lung scaring, pulmonary fibrosis, Cpt1a, lung fibrosis, idiopathic pulmonary fibrosis, sequela, ARDS, monocyte-derived macrophages, reversal