Circadian Caloric Reduction Increased Life Expectancy up to 35%

In his team’s study of hundreds of mice over four years, a reduced-calorie diet alone extended the animals’ lives by 10 percent. But feeding mice the diet only at nighttime, when mice are most active, extended life by 35 percent. That combo — a reduced-calorie diet plus a nighttime eating schedule — tacked on an extra nine months to the animals’ typical two-year median lifespan. For people, an analogous plan would restrict eating to daytime hours.

Victoria Acosta-Rodríguez, Filipa Rijo-Ferreira, Mariko Izumo, Pin Xu, Mary Wight-Carter, Carla B. Green, Joseph S. Takahashi. Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice. Science, 2022; DOI: 10.1126/science.abk0297

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Diet, fasting, circadian, longevity, lifespan, calorie restriction,  life extension, internal clock, Effects of Reducing Intake of Energy, CALERIE, Circadian alignment, aging, gene expression

#longevity #calories #circadian #fasting #aging #calories #activity #lifespan #timing