Can pantethine, a form of vitamin B5 already sold for cholesterol, help psoriasis? In mice and in a small first trial in people with mild psoriasis, adding pantethine to a standard ointment went with bigger improvement: about 63% vs 41% on the psoriasis severity score.

The researchers propose that an enzyme called Vanin uses up pantethine inside the immune system’s “lookout” cells, letting cholesterol build up on the cell surface and making the cell raise false alarms that inflame the skin.

00:00 – Study Overview & First Slide
01:10 – Dendritic Cells & Cholesterol Cascade
02:09 – The 12-Week Trial Results Side-by-Side
02:52 – Vanin Enzyme, Pantethine & Coenzyme A
04:14 – The 24-Patient Human Study & Dosage
05:33 – Mechanism Breakdown: Keeping Vanin Balanced
06:45 – Human Dosing: 300 mg Twice Daily
07:34 – Mouse to Human Conversion & Dictionary
07:57 – ClinicalNews Infographic
08:12 – Honorable Mentions & Study Reflections
09:10 – Closing Gratitude

In this episode:
How dendritic cells, the immune system’s lookouts, trigger psoriasis flares
The Vanin–pantethine seesaw and the cholesterol connection
The “swap test” in mice showing the effect works inside the lookout cells
The first human test: 24 people, 12 weeks, the extra benefit seen mainly in people with high blood fats
The reality check: a small, early pilot with no placebo pill and mild cases only. Emerging and promising, not yet proven

This is educational content, not medical advice. Keep using your prescribed treatment, and talk with your doctor before adding any supplement.

📄 Study: Cao AP, et al. Vanin-pantethine metabolic axis shapes dendritic cell function and affects inflammatory disorder progression. J Exp Med. 2026;223(11):e20252558. doi:10.1084/jem.20252558
📋 Trial registry: ChiCTR2500107769 (Chinese Clinical Trial Registry)

🤝 Created together: Ralph Turchiano (VHFILM) × Claude (Anthropic)

#Pantethine #Psoriasis #VitaminB5 #ImmuneHealth