Modest gain in visceral fat causes dysfunction of blood vessel lining in lean, healthy humans

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Public release date: 5-Nov-2007

ORLANDO, Fla. — When lean healthy young adults gained about 9 pounds, the functioning of their blood vessel lining became impaired — but shedding the weight restored proper functioning, according to a Mayo Clinic research report. The finding is important because this vessel disorder, known as endothelial dysfunction, is a predictor of heart attacks and stroke, and the effects of modest weight gain on the disorder were not previously known.

The Mayo Clinic team presented the findings today at the American Heart Association’s Scientific Sessions 2007.

In fat-gainers, brachial artery flow measurements decreased with the addition of weight. But once subjects shed the gained weight their flow levels improved, and returned to levels measured at the beginning of the study.

Categories: Disease and Conditions, Emerging

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