How does ellagic acid exert anti-cancer effect on pancreatic cancer cells?

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Public release date: 24-Sep-2008

 

Ellagic acid was previousely shown to have anticarcinogenic, antioxidant and antifibrosis properties. The anticarcinogenic effect of ellagic acid was shown in several types of cancers including skin, esophageal, and colon cancers. However the mechanisms mediating anti-cancer effect of ellagic acid, in general, remain unknown.

A research article to be published on 21 June 2008, in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Edderkaoui from West Los Angeles VA Healthcare Center showed that Ellagic acid increases programmed cell death and decreases proliferation of pancreatic cancer cells. They showed that the mechanism through which ellagic acid causes cell death is through decreasing the activity of the pro-survival transcription factor NF-kB. The compound does not affect mitochondria. The results presented in this article show for the first time how this polyphenol regulates cancer cell proliferation and resistance to death and may help surpass the resistance of these cells to radio and chemotherapies.

The data of this article demonstrate the anti-cancer properties of ellagic acid as well as its mechanism of action. This opens the possibilities of using this compound in combination with other drugs that target other pro-survival proteins to increase cell death in pancreatic cancer cells



Categories: Highlights, Missed - Medical Breakthroughs

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