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Heparin can cause skin lesions

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Public release date: 28-Sep-2009

 

 

Heparin, a commonly used anticoagulant, can cause skin lesions, reports a study http://www.cmaj.ca/press/cmaj081729.pdf in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca. Skin lesions caused by heparin may indicate the presence of a life-threatening decrease in the number of platelets, a condition called “heparin-induced thrombocytopenia” or a, in most cases self-limiting, allergic skin reaction.

The study looked at 320 patients undergoing heparin injections over 12 months at The Hospital of The Johann Wolfgang Goethe University in Frankfurt, Germany. Twenty-four patients – 7.5% of the study group – exhibited heparin-induced skin lesions, considerably above the expected rate of 2%.

“During the study, we were surprised by the high number of patients with heparin-induced skin lesions,” state Dr. Ralf Ludwig, University of Lubeck, and coauthors. For most patients, the diagnosis was made because of our study.”

After clinical examination, they suggested “a delayed-type hypersensitivity response was the most common cause for all the observed lesions,” which was confirmed by subsequent allergologic and histologic testing.

Significantly more women had hypersensitivity reactions. Pregnancy, obesity and long duration of current heparin treatment were associated with a delayed-type hypersensitivity reactions.

The authors write that physicians must be aware that skin lesions are a possibility with subcutaneous heparin therapy, and they raise awareness, that the underlying cause of the lesion should be determined.

About Post Author

Ralph Turchiano

I have a strong affinity for the sciences which led me to create my sites. My compulsion for the past decade has been reviewing literally every peer-reviewed research article. Which can easily be validated by following my posts. To me, science is where the real news is, as it will mold our destiny beyond that of politics or economics. 😉 Please feel free to e-mail: 161803p314159@gmail.com
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