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CHAPEL HILL – People who use monosodium glutamate, or MSG, as a flavor enhancer

in their food are more likely than people who don’t use it to be overweight or obese even

though they have the same amount of physical activity and total calorie intake, according

to a University of North Carolina at Chapel Hill School of Public Health study published

this month in the journal Obesity.


Researchers at UNC and in China studied more than 750 Chinese men and women, aged

between 40 and 59, in three rural villages in north and south China. The majority of study

participants prepared their meals at home without commercially processed foods. About

82 percent of the participants used MSG in their food. Those users were divided into

three groups, based on the amount of MSG they used. The third who used the most MSG

were nearly three times more likely to be overweight than non-users


“Animal studies have indicated for years that MSG might be associated with weight

gain,” said Ka He, M.D., assistant professor of nutrition and epidemiology at the UNC

School of Public Health. “Ours is the first study to show a link between MSG use and

weight in humans.”


Because MSG is used as a flavor enhancer in many processed foods, studying its

potential effect on humans has been difficult. He and his colleagues chose study

participants living in rural Chinese villages because they used very little commercially

processed food, but many regularly used MSG in food preparation.


“We found that prevalence of overweight was significantly higher in MSG users

than in non-users,” He said. “We saw this risk even when we controlled for physical

activity, total calorie intake and other possible explanations for the difference in

body mass. The positive associations between MSG intake and overweight were

consistent with data from animal studies.”


As the percentage of overweight and obese people around the world continues to

increase, He said, finding clues to the cause could be very important.

“The U.S. Food and Drug Administration and other health organizations around

the world have concluded that MSG is safe,” He said, “but the question remains – is

it healthy?”


Evil: FDA as well as others refuse to investigate the science, exposing the world to an Obesity Epidemic

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