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Scientists develop fungus-fighting vaccine

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Contact: Nickey Henry henryn@rockefeller.edu 212-327-8366 Journal of Experimental Medicine

A group of scientists in Italy have developed a vaccine with the potential to protect against fungal pathogens that commonly infect humans, according to a study by Torosantucci and colleagues in the September 5 issue of The Journal of Experimental Medicine.  Although these fungi pose little threat to people with healthy immune systems, they can cause fatal infections in those whose immune systems have been weakened by cancer treatments or post-transplant immunosuppressive therapies.  No anti-fungal vaccines are currently available.

The new vaccine was made of a sugar-like molecule called beta-glucan that is found on the cell wall of the fungus and that the fungus needs to grow and survive.  To induce a robust immune response to the vaccine, the group attached the relatively innocuous beta-glucan to a protein called diptheria toxin that is known to stimulate the immune system and has been used in other human vaccines.

The vaccine protected rodents from fatal fungal infections by triggering the production of anti-beta-glucan antibodies.  These antibodies stuck to the invading fungal cell wall and prevented the fungus from growing.  The authors now plan to test the vaccine in humans and hope the results are equally promising.

Reposted for Filing 2005

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Ralph Turchiano

I have a strong affinity for the sciences which led me to create my sites. My compulsion for the past decade has been reviewing literally every peer-reviewed research article. Which can easily be validated by following my posts. To me, science is where the real news is, as it will mold our destiny beyond that of politics or economics. 😉 Please feel free to e-mail: 161803p314159@gmail.com
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