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Contact: Jillian Hurst Journal of Clinical Investigation

Antiretroviral (ARV) drugs are the first line therapy for patients with HIV; however, ARV-treated, HIV-infected individuals still have a higher mortality rate than uninfected individuals. During the course of infection, HIV patients develop inflammation that damages the walls of the intestines, known as the gut mucosa, allowing intestinal microbes to escape and enter the blood stream to cause a life-threatening systemic infection. The health of the gut mucosa is significantly influenced by the complement of bacteria in the gut and there is mounting evidence that probiotic supplements benefit patients intestinal disorders, such as irritable bowel syndrome, C. difficile infection, and inflammatory bowel disease.

In this issue of the Journal of Clinical Investigation, researchers led by Jason Brenchley at the National Institute of Allergy and Infectious Disease, demonstrated that probiotic supplementation may also be beneficial for ARV-treated HIV patients. Brenchley and colleagues treated SIV-infected macaques (a model of human HIV-infection) with either ARV alone or ARV in combination with a mixture of probiotics. Macaques treated with probiotics had enhanced gastrointestinal immune function and decreased inflammation compared to macaques treated with ARV alone. In a companion article, Judith Aberg and colleagues at New York University School of Medicine discuss how these findings could benefit HIV patients.


TITLE: Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

AUTHOR CONTACT: Jason M. Brenchley NIAID NIH, Bethesda, MD, USA Phone: 301-496-1498; E-mail:

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TITLE: Clash of the microbes: let’s bring back the good guys

AUTHOR CONTACT: Judith Aberg New York University School of Medicine, New York, NY, USA Phone: 2122637300; Fax: ; E-mail:

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One thought on “Could probiotics help HIV patients?

  1. That’s really neat how the macaques treated with probiotics showed better symptoms, like you mentioned. My cousin has HIV and it is very difficult. We have been wondering if probiotics could potentially help her be healthier.