Ursolic acid induces neural regeneration after sciatic nerve injury
– Myelinated nerve fibers in the injured sciatic nerve were significantly increased after treatment with ursolic acid. 10 and 5 mg/kg of ursolic acid produced stronger effects than 2.5 mg/kg of ursolic acid. Our findings indicate that ursolic acid can dose-dependently increase S100 expression and promote neural regeneration in BALB/c mice following sciatic nerve injury.
– These data suggested that nerve repair and regeneration have been completed at 8 weeks, and then S100 expression levels decreased, which was close to what occurring in the low-dose ursolic acid and model groups, and nerves and muscles had undergone good recovery.”
* Neural Regen Res. Sep 25, 2013; 8(27): 2510–2519.