Ancient herbal therapy can prevent — and reverse — cardiac hypertrophy in mice
When injected into mice, honokiol (hoh-NOH’-kee-ohl) reduced the excess growth of individual cardiac muscle cells, decreased ventricular wall thickness and prevented the accumulation of interstitial fibrosis, a stiffening of cardiac muscle cells that reduces their ability to contract. It also protected heart muscle cells from the damage caused by oxidative stress, which can damage DNA.
“These results suggest that HKL is a pharmacological activator of Sirt3 capable of blocking, and even reversing, the cardiac hypertrophic response.”
* Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3 Nature Communications Published 14 April 2015 doi:10.1038/ncomms7656