( This report is Technical )
No longer a gray area: Our hair bleaches itself as we grow older and how it may be reversed.
Going gray is caused by a massive build up of hydrogen peroxide due to wear and tear of our hair follicles. The peroxide winds up blocking the normal synthesis of melanin, our hair’s natural pigment.
“All of our hair cells make a tiny bit of hydrogen peroxide, but as we get older, this little bit becomes a lot. We bleach our hair pigment from within, and our hair turns gray and then white.
The researchers made this discovery by examining cell cultures of human hair follicles. They found that the build up of hydrogen peroxide was caused by a reduction of an enzyme that breaks up hydrogen peroxide into water and oxygen (catalase). They also discovered that hair follicles could not repair the damage caused by the hydrogen peroxide because of low levels of enzymes that normally serve this function (MSR A and B). Further complicating matters, the high levels of hydrogen peroxide and low levels of MSR A and B (methionine sulfoxide reductase ), disrupt the formation of an enzyme (tyrosinase) that leads to the production of melanin in hair follicles. Melanin is the pigment responsible for hair color, skin color, and eye color.
Problem needing to be addressed
“absent catalase and methionine sulfoxide reductase A and B protein expression”
• Met – methionine sulfoxide oxidation can be prevented by l-methionine
• Topical, UVB-activated compound called PC-KUS (a modified pseudocatalase) applied directly and or catalase enxymes have been suggested but yet to be proven
* Oral Ingestion of Catalase enzymes, if delivery methods can be researched to help the enzyme reach target sites
Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair February 23, 2009, doi: 10.1096/fj.08-125435