Invasive Candida reversed by Common Herb (In Vitro)
C. albicans cells exist in different morphological states (yeast, pseudohypha, hypha) and can undergo white-opaque phenotype switching in certain conditions. The ability to convert from yeast or pseudohyphal states to the hyphal growth state is critical for systemic infection
The Candida albicans fungus also makes a biofilm, which is a fungal cell collection that can be difficult to treat. The researchers found that the gymnemic acid compounds converted the biofilm back to treatable yeast cells.
“This compound prevents the biofilm formation because hyphae are the major builders of biofilms and biofilms are resistant to antifungals,” Vediyappan said. “Yeast cells by themselves cannot make biofilms and are sensitive to antifungal treatments.”
The gymnemic acid compounds are nontoxic, which is especially important for cancer patients and other immunocompromised patients. The gymnemic acids can stop the unwanted invasive infection while preserving important healthy cells.
Gymnemic Acids Inhibit Hyphal Growth and Virulence in Candida albicans Published: September 11, 2013 DOI: