Can Vaccines change how you feel?

A quick review of three separate clinical studies, that used vaccines to induce behavior changes in healthy subjects. The original intent was to use vaccines to mimic disease like conditions in individuals. Since the hypothesis was that disease itself would alter the mood of healthy individuals. Regardless of the intent, the vaccines themselves were shown to alter behavior. Often the studies ended prior to the effected subjects behavior ever returning back to normal.

These studies reflect more on cytokine induced behavior changes, and do not look at microbiome or other biological alterations.

This segment is just to answer whether vaccine can alter mood, and not an argument for or against vaccines.

The BIG Question

If certain vaccines can cause behavior disorders in susceptible populations. Should Depression, Anxiety, PTSD, or other similar medical conditions be listed as a medical exemption for certain vaccinations?

Cited Material:
Illness, cytokines, and depression *Psychoneuroendocrinology. 1998 May;23(4):337-51.
Cytokines, “depression due to a general medical condition,” and antidepressant drugs. Adv Exp Med Biol. 1999;461:283-316.
Change in human social behavior in response to a common vaccine. Ann Epidemiol. 2010 Oct;20(10):729-33. doi: 10.1016/j.annepidem.2010.06.014
Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity Biol Psychiatry. 2009 Sep 1;66(5):407-14. doi: 10.1016/j.biopsych.2009.03.015. Epub 2009 May 7.