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Public Release: 17-Feb-2016


ISC 16 basic science tips

American Heart Association

Restoring microorganisms in the gut to a youthful age was linked to improved stroke recovery in old mice, according to a new study presented at the American Stroke Association’s International Stroke Conference 2016.

Noting that different bacteria present in the gut change with age, researchers from the University of Connecticut in Mansfield, Connecticut, used fecal transplants to deliver a “young” set of bacteria to mice that were 18 to 20 months old as well as to mice just 3 or 4 months old, while another group of mice received an “aged” set of bacteria in each of those two age groups. The mice were first given an antibiotic to suppress their own microbial makeups and allow the new sets of gut bacteria to flourish.

Follow-up behavioral and neurological tests showed that older mice with “young” sets of bacteria recovered from the induced stroke better than their peers with “aged” bacteria. Meanwhile, death rates after the stroke were particularly high — exceeding 50 percent — in young mice with “aged” bacterial makeups, researchers said.


Additional Resources:

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Future vaccine may help lower blood pressure long-term
Gut bacteria may impact body weight, fat and good cholesterol levels
Understanding stroke risk factors
Join the AHA/ASA’s Support Network to talk with others going through similar journeys including depression after stroke.
Follow news from the American Stroke Association’s International Stroke Conference 2016 via Twitter: @HeartNews #ISC16.

Statements and conclusions of study authors that are presented at American Stroke Association scientific meetings are solely those of the study authors and do not necessarily reflect association policy or position. The association makes no representation or warranty as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at

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