Missed - Medical Breakthroughs

White noise after loud noise prevents hearing deficits in mice

Public Release: 5-Jun-2017

 

Society for Neuroscience

 

Mild hearing loss from exposure to less than one hour of loud noise leads to a reorganization of circuits in a key midbrain structure of the auditory system in mice, finds new research published in The Journal of Neuroscience. However, exposure to moderate white noise for seven days immediately following loud noise prevented the reorganization of these circuits and related hearing deficits in some mice.

Karl Kandler and colleagues found that about half of mice exposed to high sound pressure levels (116 decibels) for 45 minutes were unable to detect silent gaps in background sound one week later. This gap detection deficit is interpreted in animal models as a sign of tinnitus (perceived ringing or other sound in the ear), which commonly develops after hearing loss. In both animal models and humans, tinnitus is associated with elevated activity in the inferior colliculus (IC).

Following noise exposure, the IC circuits in mice with gap detection deficits became more excitatory, which may contribute to IC hyperactivity. The authors were able to prevent these changes by exposing mice to white noise at moderate intensity (75 decibels), suggesting that noise-induced hearing loss reopens a sensitive period in the IC that could be targeted by sound therapy to treat tinnitus.

###

Article: Noise trauma induced behavioral gap detection deficits correlate with reorganization of excitatory and inhibitory local circuits in the inferior colliculus and are prevented by acoustic enrichment

DOI: https://doi.org/10.1523/JNEUROSCI.0602-17.2017

Corresponding author: Karl Kandler (University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA), kkarl@pitt.edu

Press contact: Susan Rogers, susan.rogers@pitt.edu, 412-648-7355

In order to not be misidentified as spam, please mention something in the article.

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s