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p62 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein in muscle

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Regular exercise prevents oxidative stress-induced muscle wasting, at least partially by improving the antioxidant defense system. In the present study, we found that regular endurance exercise enhances the expression of p62/SQSTM1 (p62) and its phosphorylation at Ser 351 thereby dissociating nuclear factor erythroid 2-related factor 2 (Nrf2) from Keap1, which results in increased Nrf2 nuclear translocation and DNA binding activity. These findings suggest that Ser 351 phosphorylation of p62 plays a critical role in this regulation.

Source: p62 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein in muscle

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Ralph Turchiano

I have a strong affinity for the sciences which led me to create my sites. My compulsion for the past decade has been reviewing literally every peer-reviewed research article. Which can easily be validated by following my posts. To me, science is where the real news is, as it will mold our destiny beyond that of politics or economics. 😉 Please feel free to e-mail: 161803p314159@gmail.com
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