NEW YORK, NY (OCT. 24, 2022)—In the first nationally representative study of cognitive impairment prevalence in more than 20 years, Columbia University researchers have found almost 10% of U.S. adults ages 65 and older have dementia, while another 22% have mild cognitive impairment. People with dementia and mild cognitive impairment are more likely to be older, have lower levels of education, and to be racialized as Black or Hispanic. Men and women have similar rates of dementia and mild cognitive impairment.
Although dementia and mild cognitive impairment are known to be common in the United States, accurate, up-to-date measures of their national prevalence were scarce.
“Such data are critical for understanding the causes, costs, and consequences of dementia and mild cognitive impairment in the United States, and for informing policies aimed at reducing their impact on patients, families, and public programs,” says Jennifer J. Manly, PhD, the study’s lead author and professor of neuropsychology in neurology at the Gertrude H. Sergievsky Center and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain at Columbia University.
Dementia rate 35% among people in their 90s
The study was based on data on 3,500 individuals enrolled in the nationally representative Health and Retirement Study. Between 2016 and 2017, each participant completed a comprehensive set of neuropsychological tests and in-depth interviews, which were used to develop an algorithm for diagnosing dementia or mild cognitive impairment.
Dementia and Mild Cognitive Impairment
Dementia is characterized by cognitive difficulties that begin in adulthood and affect a person’s ability to independently perform everyday activities. Mild cognitive impairment is a classification assigned to people who are thought to be transitioning between normal aging and dementia, but not everyone who has mild cognitive impairment will go on to develop dementia.
Rates of dementia and mild cognitive impairment rose sharply with age: 3% of people between 65 and 69 had dementia, rising to 35% for people age 90 and over.
“With increasing longevity and the aging of the Baby Boom generation, cognitive impairment is projected to increase significantly over the next few decades, affecting individuals, families, and programs that provide care and services for people with dementia,” Manly says.
The economic impact of dementia, including unpaid family caregiving, is estimated to be $257 billion per year in the United States and $800 billion worldwide.
Disparities in cognitive impairment are driven by exposure to structural and social inequalities
Unlike previous large studies of dementia in the United States, participants in the new study are representative of older adults, enabling researchers to examine differences in the national prevalence of dementia and mild cognitive impairment by age, race and ethnicity, gender, and education.
The data show a disproportionate burden of dementia among older adults who self-identified as Black or African American, of mild cognitive impairment among older adults who identify as Hispanic, and both categories of cognitive impairment among people who had fewer opportunities to obtain education.
Dementia MCI Black/African American 15% 22% Hispanic/Latino 10% 28% White 9% 21% Less than high school 13% 30% College degree or more 9% 21%
“Dementia research in general has largely focused on college-educated people who are racialized as white,” says Manly. “This study is representative of the population of older adults and includes groups that have been historically excluded from dementia research but are at higher risk of developing cognitive impairment because of structural racism and income inequality. If we’re interested in increasing brain health equity in later life, we need to know where we stand now and where to direct our resources.”
The study was published online Oct. 24 in the journal JAMA Neurology.
The study is titled, “Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project.”
The other contributors: Richard N. Jones (Brown University Warren Alpert Medical School), Kenneth M. Langa (University of Michigan), Lindsay H. Ryan (University of Michigan), Deborah A. Levine (University of Michigan and Veterans Affairs Center for Clinical Management Research, Ann Arbor), Ryan McCammon (University of Michigan), Steven G. Heeringa (University of Michigan), and David Weir (University of Michigan).
Columbia University Irving Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the Vagelos College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Irving Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast. For more information, visit cuimc.columbia.edu or columbiadoctors.org.
METHOD OF RESEARCH
SUBJECT OF RESEARCH
Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US: The 2016 Health and Retirement Study Harmonized Cognitive Assessment Protocol Project
ARTICLE PUBLICATION DATE
Manly, Jones, Langa, Ryan, Heeringa, and Weir reported grants from the National Institute on Aging during the conduct of the study. Langa reported grants from the National Institute on Aging and the Alzheimer’s Association outside the submitted work and reported having provided expert testimony related to decisional capacity of an individual with dementia. Levine reported consulting fees from the National Institutes of Health and serving as principal investigator or coinvestigator on projects funded by grants from the National Institutes of Health as well as on the data safety monitoring board for the National Institutes of Health during the conduct of the study. Weir reported grants from the National Institute on Aging outside the submitted work. No other disclosures were reported.
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