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Academic Summary:
d-Limonene (LIM) has emerged as an exceptionally effective dietary bioactive for the treatment of gout and hyperuricemia. This 2026 study demonstrates that LIM provides multi-level protection by suppressing the NLRP3-IL-1β inflammatory axis and restoring redox homeostasis through the elevation of endogenous antioxidants like SOD and GSH. Beyond its anti-inflammatory efficacy, LIM acts as a powerful nephroprotective and hepatoprotective agent, preserving renal and hepatic integrity even under metabolic stress. These findings position d-Limonene as a premier nutraceutical adjuvant for comprehensive gout management.

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Venkatesan K, Muralidharan P, Sivadasan D, et al. Dose-Sparing Efficacy of d-Limonene with Low-Dose Allopurinol in a Dual Model of Hyperuricemia and Gouty Arthritis in Rats. Nutrients. 2026;18(72):1-21. doi:10.3390/nu18010072.

MEDICAL DISCLAIMER: This content is based on preclinical research and is for informational purposes only. It does not constitute medical advice. Always consult a physician before starting new supplements.