Public release date: 3-Oct-2011
The number of individuals with type 2 diabetes is reaching epidemic proportions. One of the main risk factors for developing type 2 diabetes is resistance of the cells in the body to the effects of the hormone insulin. Chu-Xia Deng and colleagues, at the National Institutes of Health, Bethesda, have now identified a new molecular pathway that helps mice remain sensitive to the effects of insulin. Disruption of this pathway in liver cells gradually led to whole-body insulin resistance in older mice that could largely be reversed by treatment with an antioxidant. Deng and colleagues therefore suggest that antioxidants might help protect older humans from progressive insulin resistance and thereby reduce their risk of developing type 2 diabetes.
TITLE: Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance