Decreased recognition of the Delta variant after a 2nd vaccine dose suggested a dominant focusing response toward the Wuhan variant at the expense of VOC-recognizing clones

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Differential antibody dynamics to SARS-CoV-2 infection and vaccination

Quote” Decreased recognition of the Delta variant after a 2nd vaccine dose suggested a dominant focusing response toward the Wuhan variant at the expense of VOC-recognizing clones” Found in the last paragraph of the Discussion (Full Study) Section as well as other segments of the study.

Abstract

Optimal immune responses furnish long-lasting (durable) antibodies protective across dynamically mutating viral variants (broad). To assess robustness of immunity induced by mRNA vaccination, we compared durability and breadth after SARS-CoV-2 infection and vaccination. While vaccination delivered robust initial virus-specific antibodies with some cross-variant coverage, pre-variant SARS-CoV-2 infection-induced antibodies, while modest in magnitude, showed highly stable long-term antibody dynamics. Vaccination after infection induced maximal antibody magnitudes with enhanced longitudinal stability while infection-naïve vaccinee antibodies fell with time to post-infection-alone levels. The composition of antibody neutralizing activity to variant relative to original virus also differed between groups, with infection-induced antibodies demonstrating greater relative breadth. Differential antibody durability trajectories favored COVID-19-recovered subjects with dual memory B cell features of greater early antibody somatic mutation and cross-coronavirus reactivity. By illuminating an infection-mediated antibody breadth advantage and an anti-SARS-CoV-2 antibody durability-enhancing function conferred by recalled immunity, these findings may serve as guides for ongoing vaccine strategy enhancement.

Competing Interest Statement

The authors have declared no competing interest.

Paper in collection COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

Differential antibody dynamics to SARS-CoV-2 infection and vaccinationYuezhou Chen, Pei Tong, Noah B. Whiteman, Ali Sanjari Moghaddam, Adam Zuiani, Shaghayegh Habibi, Avneesh Gautam, Tianshu Xiao, Yongfei Cai, Bing Chen, Duane R. WesemannbioRxiv 2021.09.09.459504; doi: https://doi.org/10.1101/2021.09.09.459504



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