People with IBD have more microplastics in their feces, study says

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Microplastics — tiny pieces of plastic less than 5 mm in length –– are everywhere, from bottled water to food to air. According to recent estimates, people consume tens of thousands of these particles each year, with unknown health consequences. Now, researchers reporting in ACS’ Environmental Science & Technology found that people with inflammatory bowel disease (IBD) have more microplastics in their feces than healthy controls, suggesting that the fragments could be related to the disease process.

The prevalence of IBD, which includes Crohn’s disease and ulcerative colitis, is rising globally. Characterized by chronic inflammation of the digestive tract, IBD can be triggered or made worse by diet and environmental factors. Microplastics can cause intestinal inflammation, gut microbiome disturbances and other problems in animal models, so Faming Zhang, Yan Zhang and colleagues wondered if they could also contribute to IBD. As a first step toward finding out, the researchers wanted to compare the levels of microplastics in feces from healthy subjects and people with different severities of IBD.

The team obtained fecal samples from 50 healthy people and 52 people with IBD from different geographic regions of China. Analysis of the samples showed that feces from IBD patients contained about 1.5 times more microplastic particles per gram than those from healthy subjects. The microplastics had similar shapes (mostly sheets and fibers) in the two groups, but the IBD feces had more small (less than 50 μm) particles. The two most common types of plastic in both groups were polyethylene terephthalate (PET; used in bottles and food containers) and polyamide (PA; found in food packaging and textiles). People with more severe IBD symptoms tended to have higher levels of fecal microplastics. Through a questionnaire, the researchers found that people in both groups who drank bottled water, ate takeaway food and were often exposed to dust had more microplastics in their feces. These results suggest that people with IBD may be exposed to more microplastics in their gastrointestinal tract. However, it’s still unclear whether this exposure could cause or contribute to IBD, or whether people with IBD accumulate more fecal microplastics as a result of their disease, the researcher say.

The authors acknowledge funding from the National Natural Science Foundation of China.

The paper’s abstract will be available on December 22 at 8 a.m. Eastern time here: http://pubs.acs.org/doi/abs/10.1021/acs.est.1c03924

The American Chemical Society (ACS) is a nonprofit organization chartered by the U.S. Congress. ACS’ mission is to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and all its people. The Society is a global leader in promoting excellence in science education and providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, eBooks and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research. As a leader in scientific information solutions, its CAS division partners with global innovators to accelerate breakthroughs by curating, connecting and analyzing the world’s scientific knowledge. ACS’ main offices are in Washington, D.C., and Columbus, Ohio.

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Source: People with IBD have more microplastics in their feces, study says



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