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COLITIS, Intestinal Bowel Disease greatly helped by Urolithin A

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COLITIS, Intestinal Bowel Disease greatly helped by Urolithin A

Administration of these agents after mice have developed full colitis has reversed the phenotype significantly by reducing shortening of colons, gut permeability, and inflammation. When animals were fed with UroA or its synthetic analog prior to insulting with TNBS, mice did not develop colitis. Therefore, proving the protective nature of these compounds against gut inflammation. These results suggest that UroA/UAS03 mediated enhanced gut barrier function will likely have long-term beneficial effects in preventing colitis.

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

doi.org/10.1038/s41467-018-07859-7DO – 10.1038/s41467-018-07859-7ID – Singh2019ER

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Ralph Turchiano

I have a strong affinity for the sciences which led me to create my sites. My compulsion for the past decade has been reviewing literally every peer-reviewed research article. Which can easily be validated by following my posts. To me, science is where the real news is, as it will mold our destiny beyond that of politics or economics. 😉 Please feel free to e-mail: 161803p314159@gmail.com
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