“When we gave the AD animals this enzyme inhibitor, we saw the rescue of cognitive function confirmed through evaluations of recognition memory, spatial memory and working memory. We were quite surprised to see such dramatic cognitive improvement,” Yan said. “At the same time, we saw the recovery of glutamate receptor expression and function in the frontal cortex.”

#Alzheimers #BIX01294 #reversed

Yan Zheng, Aiyi Liu, Zi-Jun Wang, Qing Cao, Wei Wang, Lin Lin, Kaijie Ma, Freddy Zhang, Jing Wei, Emmanuel Matas, Jia Cheng, Guo-Jun Chen, Xiaomin Wang, Zhen Yan; Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease, Brain, , awy354, https://doi.org/10.1093/brain/awy354

https://academic.oup.com/brain/advanc…

https://www.nature.com/articles/s4138…