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The high-fat, low-carbohydrate ketogenic diet is more than just a trendy weight-loss tactic. It has also been known to help control seizures in children with epilepsy, particularly those who don’t respond to first-line anti-seizure medications. In a new UCLA study published in the journal Cell Reports, researchers demonstrate that the changes the diet causes in the human gut microbiome — the trillions of bacteria and other microorganisms that live in the digestive tract — can confer protection against seizures in mice. Understanding how the function of the microbiome is altered by the diet could aid in the development of new therapeutic approaches […]
“[…] murine models proved to be valuable and, in some cases, indispensable for advancing melatonin applications in oncology […].” BUFFALO, NY- December 18, 2023 – A new research perspective was published in Oncotarget’s Volume 14 on December 12, 2023, entitled, “Melatonin and carcinogenesis in mice: the 50th anniversary of relationships.” Fifty years ago, in 1973, Vladimir N. Anisimov and coauthors demonstrated for the first time an inhibitory effect of the pineal gland hormone melatonin on cancer in vivo, namely on transplantable mammary tumors in mice. Subsequently, it was shown in a number of studies that melatonin administration with drinking water at night inhibits chemically induced mammary carcinogenesis […]
This study investigated the effects of consuming a combination of Bifidobacterium animalis subsp. lactis GCL2505 and inulin on abdominal fat reduction. The results showed that participants who consumed the combined beverage had significant reductions in visceral fat area and total fat area compared to the placebo group. Additionally, the intervention increased the total number of bifidobacteria in the gut and affected several lipid markers. The authors suggest that the combined intake of GCL2505 and inulin improves the intestinal environment and reduces abdominal fat through a mechanism involving short-chain fatty acids (SCFAs). Further research is needed to investigate the full mechanisms […]
Aging poses a number of challenges to the body’s well-being, one of the most important being an increased susceptibility to multiple diseases, including urinary tract infections (UTIs). The connection between aging and more prevalent UTIs is not well understood, but now researchers at Baylor College of Medicine have found an explanation. The researchers show in the journal Developmental Cell that, compared to the younger counterpart, the aging urinary tract in animal models changes how it functions at the cellular level in ways that seem to favor the establishment and recurrence of UTIs. Furthermore, the researchers also found that the sugar D-mannose reduces […]
(Santa Barbara, Calif.) — It’s official: The ketogenic diet proved to be effective at controlling polycystic kidney disease (PKD) in the first randomized controlled clinical trial of ketogenic metabolic therapy for PKD. “I’m really happy about these clinical trial results,” said UC Santa Barbara biologist Thomas Weimbs, whose lab was part of an international collaboration to investigate the effect of the fasting response known as ketosis on the cysts that are the hallmark of the disease. “We now have the first evidence in humans that the cysts really don’t like to be in ketosis and that they don’t seem to grow.” […]
A new study published in The Journal of Nutrition shows daily consumption of prunes may reduce inflammation markers connected to bone signaling pathways and reduce the effects of bone loss among postmenopausal women. “Bone loss is a significant issue impacting more than 50% of women over the age of 50, and there is no cure,” said Principal Investigator Mary Jane De Souza, PhD, Professor, Department of Kinesiology, Pennsylvania State University. “While medications and hormone therapies are available, they often require lifelong management and come with risks. It’s important to have a better understanding of how non-pharmacological approaches – like lifestyle and dietary choices—can also […]
At least 75 per cent of type 2 diabetes cases could be avoided by adopting a healthy lifestyle. A plant-based diet has been shown to play a key role in this. With limitations – as demonstrated in a study led by Tilman Kühn from MedUni Vienna’s Center for Public Health: A more plant-based diet only develops its protective effects if not only the consumption of animal-based foods, but also industrially processed and highly sugary foods is reduced. For the first time, the scientists identified improvements in metabolism and liver and kidney function as reasons for the positive effects of a […]
For decades, scientists have noted an intriguing similarity between a deficiency in vitamin B12 – an essential nutrient that supports healthy development and functioning of the central nervous system (CNS) – and multiple sclerosis (MS), a chronic disease in which the body’s immune system attacks the CNS and which can produce neurodegeneration. Both vitamin B12 (also known as cobalamin) deficiency and MS produce similar neurological symptoms, including numbness or tingling in hands and feet, vision loss, difficulty walking or speaking normally and cognitive dysfunction, such as problems with memory. In a new study, published online December 8, 2023 in Cell Reports, researchers at […]
A new study by Johns Hopkins Medicine suggests that epigallocatechin gallate (EGCG), a compound found in green tea, could be a promising treatment for uterine fibroids. The study found that EGCG reduced the protein levels of fibronectin, a protein involved in fibroid growth, by up to 52%. Additionally, EGCG disrupted pathways involved in fibroid tumor cell growth, movement, signaling and metabolism. These results suggest that EGCG may be an effective way to treat and prevent uterine fibroids. #EGCG #GreenTea #fibroidtreatment Islam, M. S., Parish, M., Brennan, J. T., Winer, B. L., & Segars, J. H. (2023). Targeting fibrotic signaling pathways […]
Washington, D.C.— A new study demonstrates that the human gut microbiome may be a factor in breast health. Lifestyle and diet have long been known to affect human health. In the study, flaxseed components called lignans were shown to influence the relationship between gut microorganisms and the expression of mammary gland microRNAs (miRNAs). A subset of these miRNAs regulates the genes involved in breast cancer, including genes that control cell proliferation and migration. The study was published in Microbiology Spectrum, a journal of the American Society for Microbiology. “The gastrointestinal microbiota plays an important role in modifying many components of our diet […]
WHO: Mass General Brigham researchers, Dr. Chirag Vyas and Dr. Olivia I. Okereke at Massachusetts General Hospital, and Dr. Howard Sesso and Dr. JoAnn Manson at Brigham and Women’s Hospital WHAT: Cocoa extract has shown a potential protective effect on cognition but randomized clinical trials in older adults have had inconsistent results. A new study of cognition in a randomized trial, known as the Cocoa Supplement and Multivitamin Outcomes Study (COSMOS), suggests that taking cocoa extract supplements containing 500 mg per day of cocoa flavanols had cognitive benefits for older adults who had lower habitual diet quality at the time of enrollment […]
Twice daily non-invasive electrical stimulation of the brain may boost mental processes (cognitive function) in people with Alzheimer’s disease, suggest the results of a small clinical trial published online in the open access journal General Psychiatry. The technology, known as transcranial direct current stimulation, or tDCS for short, may help to fire up the brain’s plasticity, enabling ‘rewiring’ through the formation of new neural networks, the findings suggest. tDCS comes in the form of a device with two electrodes, placed over specific areas of a person’s head, which deliver a constant low intensity electrical current. It is starting to be used […]
New research could one day pave the way for the treatment of vaginal yeast infections, by shedding new light on how microbes in the body absorb zinc. Around three quarters of women develop vaginal yeast infections at least once in their lifetime, and approximately 140 million women globally suffer from recurrent infections. Recurrent yeast infections can have an enormous impact of quality of life. Existing anti-fungal treatments are not always effective and resistance against these treatments is developing. Thrush is caused by a yeast called Candida. There are a number of species of Candida, but the one that causes most yeast […]
This trial examined the effects of H. erinaceus on cognitive function and mood in young adults. Participants took a single 1.8 g dose of H. erinaceus and then supplemented for 28 days. Results showed faster performance on the Stroop task with a single dose and a potential stress-reducing effect with supplementation. #lionsmanemushroom #brainhealth #stressrelief Docherty, S., Doughty, F. L., & Smith, E. F. (2023). The Acute and Chronic Effects of Lion’s Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients, 15(22), 4842. https://doi.org/10.3390/nu15224842 Hericium erinaceus , lions mane benefits, lions […]
The national park of Koli in eastern Finland is home to a famous, 34-metre-long crevice cave known as Pirunkirkko, or Devil’s Church in English. In folklore, this crevice cave was known as a place where local sages would meet to contact the spirit world. Even today, the place is visited by practitioners of shamanism, who organise drumming sessions in the cave. A new article by Riitta Rainio, a researcher of archaeology at the University of Helsinki, and Elina Hytönen-Ng, a researcher of cultural studies at the University of Eastern Finland, investigates the acoustics of the Devil’s Church and explores whether […]
The Physicians Committee for Responsible Medicine has conducted a study that shows a low-fat vegan diet, which includes soy, can significantly reduce postmenopausal vasomotor symptoms, commonly known as hot flashes. The study observed a 95% decrease in hot flashes overall, while severe hot flashes were completely eliminated. Moderate-to-severe hot flashes decreased by 96%, and daytime and nighttime hot flashes reduced by 96% and 94%, respectively. In addition, participants on the vegan diet lost an average of 6.4 pounds. #MenopauseRelief #HotFlashes #NightSweats Kahleova, H., Holtz, D. N., Strom, N., La Reau, A., Kolipaka, S., Schmidt, N., Hata, E., Znayenko-Miller, T., Holubkov, […]
One of the primary chlorine disinfectants currently being used to clean hospital scrubs and surfaces does not kill off the most common cause of antibiotic associated sickness in healthcare settings globally, according to a new study. Research by the University of Plymouth has showed spores of Clostridioides difficile, commonly known as C. diff, are completely unaffected despite being treated with high concentrations of bleach used in many hospitals. In fact, the chlorine chemicals are no more effective at damaging the spores when used as a surface disinfectant – than using water with no additives. Writing in the journal Microbiology, the study’s authors […]
Type 2 diabetes and Time-restricted Eating breakthrough? Ep. 1163 NOV 2023 Study shows intermittent fasting helps Type 2 diabetics manage weight and blood sugar levels. Participants who ate within an 8-hour window lost more weight in 6 months than those who reduced calorie intake by 25%. No adverse events or blood sugar issues reported. #TRE #timerestrictedeating #diabetes Pavlou V, Cienfuegos S, Lin S, et al. Effect of Time-Restricted Eating on Weight Loss in Adults With Type 2 Diabetes: A Randomized Clinical Trial. JAMA Netw Open. 2023;6(10):e2339337. doi:10.1001/jamanetworkopen.2023.39337 time-restricted eating, type 2 diabetes, intermittent fasting, type 2 diabetes diet breakthrough, reverse […]
In brief: 3D printing is advancing rapidly, and the range of materials that can be used has expanded considerably. While the technology was previously limited to fast-curing plastics, it has now been made suitable for slow-curing plastics as well. These have decisive advantages as they have enhanced elastic properties and are more durable and robust. The use of such polymers is made possible by a new technology developed by researchers at ETH Zurich and a US start-up. As a result, researchers can now 3D print complex, more durable robots from a variety of high-quality materials in one go. This new […]
Barcelona, 16 November 2023 – Vitamin B12 is a well-known micronutrient that has long been acknowledged for its essential role in maintaining nerve function, supporting red blood cell production, and facilitating DNA synthesis, all vital processes for overall health. Researchers led by Dr. Manuel Serrano at IRB Barcelona have now revealed that vitamin B12 also plays a pivotal role in cellular reprogramming and tissue regeneration. The findings have been published in the journal Nature Metabolism The research was focused on an experimental process known as cellular reprogramming which is thought to mimic the early phases of tissue repair. The IRB team found that cellular […]
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